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EC number: 203-558-5
CAS number: 108-18-9
contact hypersensivity of Diisopropylamine (DIPA) was evaluated in
Guinea pigs according a protocol similar to OECD N°406 guideline
(Magnusson and Kligman maximalisation test). The induction phase has
been realized both by intradermal route on day 1 (DIPA 0.1% in water)
and by cutaneous route on day 8 (DIPA 10%) in 2 groups of guinea pigs: 5
males and 5 females for control group and 10 males and 10 females for
treated group. The challenge phase was realized on day 20 by cutaneous
application of DIPA 10%; the cutaneous reactions were scored 24 and 48
hours after the challenge phase. After the challenge application, a very
slight to well-defined erythema (scores of 1 and 2 in 5/10 control
animals and in 5/20 treated animals) or moderate to severe erythema
(score of 3 in 4/20 treated animals) were recorded. These reactions
persisted at 48hours. The histological examination which was performed
on the skin samples taken from the animals with cutaneous reactions,
revealed the presence of slight to moderate lesions in the control and
treated animals. These lesions consisted of an hyperkeratosis,
acanthosis, mononuclear or polynuclear cell infiltration, haemorrhages,
vascular ectasia and epidermic necrosis. The lesions were slightly more
marked in the treated animals when compared to those noted in tne
control animals. In the presence of a well-defined epidermic necrosis in
the control animais and in the absence of an oedema or a spongiose in
the treated animals, the cutaneous reactions which were recorded were
considered as a result of an orthoergenic process of the test substance. Under
these experimental conditions, DIPA at a concentration of 10% in water
induced slight to marked cutaneous reactions as a result of irritant
process in 5 control animals and 9 treated animals.
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