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Description of key information

Diisopropylamine is irritative for the respiratory tract.

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The nasal irritation produced by Diisopropylamine was studied using male Swiss OF1mice. Groups of six mice each were exposed to concentrations of Diisopropylamine ranging from 88 to 351 ppm in air for 15 min to determine the concentration at which the respiratory rate was decreased by 50% (RD50) (Gagnaire et al., 1989 and 1993). The head of each mouse was isolated in an inhalation chamber, and the breathing frequency was measured with a pressure transducer before and during the exposure period. The RD50for Diisopropylamine was 161 ppm, and maximal effects were observed within 0.5 to 1 min.The authors also exposed groups of mice to 29 to 207 ppm of Diisopropylaminevia tracheal cannulation for 120 min. The concentration that caused a 50% decrease in respiratory rate via this route (RD50TC) was compared with the RD50 (161 ppm). The RD50TC was 102 ppm, and maximal effects were observed after 120 min of exposure. The authors noted that the RD50TC/RD50ratio was less than 1 (0.6), which indicated that Diisopropylamine primarily caused lower airway effects.