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Description of key information

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential
Absorption rate - oral (%):
100
Absorption rate - dermal (%):
10
Absorption rate - inhalation (%):
100

Additional information

There is no toxicokinetics, metabolism and distribution data available on diisopropylamine. Therefore, the assessment of the toxicokinetics of diisopropylamineis based on the available toxicological data and the physicochemical properties as suggested by the REACH Guidance Chapter R.7c:

Molecular weight: 101.2 g/mole

Water solubility: miscible

Partition coefficient log Kow = 0.4 at pH 12 and at 20°C

ABSORPTION

Oral route

According to the REACH Guidance, the physicochemical characteristics of diisopropylamine (log Pow 0.4) and the molecular mass (101.2 g/mol) are in a range suggestive of absorption as such from the gastro-intestinal tract subsequent to oral ingestion. This assumption of oral absorption is confirmed by the mortality observed from 250 mg/kg bw in the acute oral toxicity study in rats (Auletta, 1985) and the NOAEL of 50 mg/kg bw/d in the oral 4-week toxicity study in rats (Verschuere, 1991).

Therefore, the oral absorption of diisopropylaminecan be assumed to be 100% for risk assessment.

Inhalation route

According to the REACH Guidance, the physicochemical characteristics of diisopropylamine (log Pow 0.4) and the molecular mass (101.2 g/mol) are in a range suggestive of absorption as such from the respiratory subsequent to inhalation exposure. This assumption of absorption is supported by the results of the acute inhalation toxicity studies (BASF, 1979; Price et al., 1979). Therefore, the inhalation absorption can be assumed to be 100% for risk assessment.

Dermal absorption

According to the REACH Guidance, the n-Octanol/water partition coefficient (log Pow), the water solubility and molecular weight of diisopropylamine are in ranges which favour dermal absorption. This assumption of absorption is supported by the mortality observed at 5000 mg/kg in the acute dermal toxicity study in rats (BASF, 1977). In such circumstances, a default value of 100% skin absorption is generally used. However, when compared to the acute oral toxicity data, mortality by dermal administration was observed at a dose level 20 times higher, indicating a significant lower dermal absorption. A default value of 10% for skin absorption will be used for risk assessment.

DISTRIBUTION and METABOLISM

According to the REACH Guidance, as a small molecule a wide distribution of diisopropylamine is expected.

Diisopropylamine is predicted to be initially oxidized to acetone and either isopropylamine or N-hydroxy-isopropylamine. The actual predominant metabolic route of DIPA is unknown.

ELIMINATION

According to the REACH Guidance, the n-Octanol/water partition coefficient (log Pow of 0.4) is not suggestive of accumulation of unchanged diisopropylamine in fatty tissues subsequent to absorption.