Registration Dossier

Administrative data

Endpoint:
health surveillance data
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
The physiological response of animals to respiratory exposure to the vapors of diisopropylamine
Author:
Treon JF, Sigmon H, Kitzmiller KV and Heyroth FF
Year:
1949
Bibliographic source:
Journal of Industrial Hygiene and Toxicology 31: 142-145

Materials and methods

Study type:
health record from industry
Endpoint addressed:
acute toxicity: inhalation

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Applicant's summary and conclusion

Executive summary:

Transient dimness of vision and, in a few instances, nausea and headaches were reported among men engaged in the distillation of diisopropylamine in a pilot plant operation. The visual distress occurred within 2 to 3 hours after exposure to unusually high concentrations of the vapour and persisted for one to 2 hours after the men went out into fresh air. The mean concentration of diisopropylamine in the pilot plant were said to be of the order of 100 to 200 mg/m3 (ca. 25-50 ppm), with 5-10-minute peaks of about 740 mg/m3 (ca. 180 ppm), occurring 2 or 3 times daily, near a drum into which diisopropylamine was being drained.