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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
No information
Author:
Chapman and Hall
Year:
1959
Bibliographic source:
Williams, R. T. Detoxication Mechanisms 1959, Chapman and Hall, London, UK.
Reference Type:
review article or handbook
Title:
DOSE Doc. no.: P73
Author:
RSC Publishing
Year:
2011
Bibliographic source:
Dictionary of Substances and their effects (DOSE);Williams, R. T. Detoxication Mechanisms 1959, Chapman and Hall, London, UK.
Reference Type:
other: Authoritative data base
Title:
HSDB Number : 112
Author:
HSDB database
Year:
2011
Bibliographic source:
HSDB (Hazardous Substances Data Bank); US national Library of Medicine reviewed by SRC:-Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982; p.2525
Reference Type:
other: Authoritative data base
Title:
GCID : 11048
Author:
ACToR database
Year:
2011
Bibliographic source:
ACToR (Aggregated Computational Toxicology Resource):-[Clayton, G. D. and F. E. Clayton (eds.). Pattys Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 2525]**PEER REVIEWED**

Materials and methods

Objective of study:
excretion
Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
Data is taken from DOSE handbook and HSDB, ACToR database
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Phenetole
- Substance type: Organic
- Physical state: Liquid
Radiolabelling:
not specified

Test animals

Species:
other: no data
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: no data
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Main ADME resultsopen allclose all
Type:
metabolism
Results:
Hydroxylated in the para position
Type:
excretion
Results:
excreted as glucuronide and ethereal sulfate

Toxicokinetic / pharmacokinetic studies

Details on excretion:
Phenetole, like Anisole, is hydroxylated in para position & excreted as glucuronide & ethereal sulfate

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
glucuronide and ethereal sulfate

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): low bioaccumulation potential based on study results
Phenetole is hydroxylated in its para position & excreted as metabolites glucuronide & ethereal sulfate. Also, the bio-accumulation potential of the chemical varied from 21 to 48 (very low value that does not suggest bio-accumulation). Thus, considering these facts, the bio-accumulation potential of phenetole appears to be low.
Executive summary:

Phenetole is hydroxylated in its para position & excreted as metabolites glucuronide & ethereal sulfate. Also, the bio-accumulation potential of the chemical varied from 21 to 48 (very low value that does not suggest bio-accumulation). Thus, considering these facts, the bio-accumulation potential of phenetole appears to be low.