Registration Dossier

Administrative data

Endpoint:
chronic toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
"Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia"
Author:
Bandman A.L. et al.
Year:
1994
Bibliographic source:
"Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year: -,289,1994
Reference Type:
review article or handbook
Title:
RTECS Number : BZ8050000
Author:
RTECS database
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances):- VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year: -,289,1994

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
Data is from RTECS database
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Substance Name: anisole

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
122 days
Frequency of treatment:
Intermittent
Control animals:
not specified

Results and discussion

Effect levels

Dose descriptor:
other: TCLo
Effect level:
200 mg/m³ air
Based on:
test mat.
Sex:
not specified
Basis for effect level:
other: not specified
Remarks on result:
other: not specified

Target system / organ toxicity

Critical effects observed:
not specified
System:
other: not specified
Organ:
not specified
Treatment related:
not specified
Dose response relationship:
not specified
Relevant for humans:
not specified

Applicant's summary and conclusion

Conclusions:
The repeated dose toxicity TCLo(Lowest published toxic concentration) of anisole was observed at a dose concentration of 200 mg/m3 air in a 122 days study period where the dosage of anisole was intermittently given to rodent-rat by inhalative route.This indicates that anisole shall not exhibit toxic effect to rodent-rat by the inhalative route below the above mention dose.
Executive summary:

The repeated dose toxicity TCLo(Lowest published toxic concentration) of anisole was observed at a dose concentration of 200 mg/m3 air in a 122 days study period where the dosage of anisole was intermittently given to rodent-rat by inhalative route.This indicates that anisole shall not exhibit toxic effect to rodent-rat by the inhalative route below the above mention dose.