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EC number: 203-139-7 | CAS number: 103-73-1
Phenetole like its analogue chemical anisole is hydroxylated in para position and excreted as glucuronide. Since metabolism in most cases leads to detoxification (no toxic effects were observed with anisole upon oral administration) and the metabolites are excreted out of the living system; based on the read-across principle; bio-accumulation potential of phenetole appears to be low.
Acute toxicity of phenetole to mouse by the oral route indicates that the substance does not exhibits acute toxicity by the oral route. Similarly the acute values of inhalation for read across substance that is anisole on rats, indicates that the substance does not exhibits acute toxicity by the inhalative route.Moreover the acute toxicity of a similar substance, 4-Methylanisole, on rabbits by the dermal route indicates that the substance does not exhibits acute toxicity by the dermal route. Thus, it can be inferred that the target substance is non toxic to any of the oral, dermal and inhalation route of exposure.
Irritation / corrosion
In vivo studies of the substance show that the substance is non irritating to skin and eyes, and so the substance is not classified in any of the category as per the C&L regulation.
According to the quantitative structure activity relationship model prediction, Phenetole was predicted as not being sensitizing to guinea pig skin by Guinea pig maximisation test.
Phenetole is non acute toxic to oral, dermal and inhalation route, shows no irritation effect to skin and eye, is not genotoxic and is not a developmental or reproductive toxin.
In the absence of local effects following short-term or long-term exposure, no dose-response data are available and a quantitative dose descriptor is not derived. DNEL values for local exposure are therefore not calculated.
In the absence of acute systemic toxicity, no dose-response data are available and a quantitative dose descriptor is not derived. DNEL values for acute systemic effects are therefore not calculated.
A standard approach to deriving DNEL values would be to use the repeated dose toxicity dataset and apply assessment factors as described in ECHA guidance documents. The critical endpoint is considered to be the NOAEL of 4375 mg/kg bw/d in oral category.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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