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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
DPIM: DPIM:
Author:
Richard J. Lewis, Sr.
Year:
2007
Bibliographic source:
SAX (Sax's Handbook of Dangerous Industrial Materials);RMSRA6    Revue Medicale de la Suisse Romande. 15 (1895), 561.
Reference Type:
review article or handbook
Title:
RTECS Number : SI7700000
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances); RMSRA6 Revue Medicale de la Suisse Romande. (Societe Medicale de La Suisse Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland) V.1- 1881- Volume(issue)/page/year: 15,561,1895
Reference Type:
review article or handbook
Title:
DOSE Doc. no.: P73
Author:
RSC Publishing
Year:
2011
Bibliographic source:
Dictionary of Substances and their effects (DOSE);Rev. Med. Suisse Romande 1895, 15, 561.
Reference Type:
publication
Title:
Revue Medicale de la Suisse Romande
Year:
1895
Bibliographic source:
Societe Medicale de La Suisse Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland V.1- 1881- Volume(issue)/page/year: 15,561,1895

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
Data is from RTECS,DOSE,SAX
GLP compliance:
not specified
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): phenetole
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LDLo
Effect level:
3 500 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Conclusions:
Acute toxicity to rat by subcutaneous route examined at dose concentration 3500 mg/kg showed Toxic Effects:Behavioral - altered sleep time
(including change in righting reflex) Behavioral - tremor Liver - fatty liver degeneration
Executive summary:

Acute toxicity to rat by subcutaneous route examined at dose concentration 3500 mg/kg showed Toxic Effects:Behavioral - altered sleep time (including change in righting reflex) Behavioral - tremor Liver - fatty liver degeneration