Registration Dossier

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Monographs on Fragrance Raw Materials
Author:
D. L. J. OPDYKE F
Year:
1979
Bibliographic source:
Food & cosmetic toxicology . Vol 17. pp 241 to 275

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Not available
GLP compliance:
not specified
Test type:
other: No data

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
Not available

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
Not available

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
Details not available
Duration of exposure:
Details not available
Doses:
Details not available
No. of animals per sex per dose:
Details not available
Control animals:
not specified
Details on study design:
Details not available

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Non toxic
Mortality:
Details not available
Clinical signs:
Details not available

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
A dermal LD50 study was conducted in which 5000 mg/kg of Anisole was applied to the skin of rabbits. The animals were observed for mortality and/or systemic effects for 14 days. No further details were provided. Acute dermal LD50/rabbits > 5000 mg/kg bw was determined.
Executive summary:

A dermal LD50 study was conducted in which 5000 mg/kg of Anisole was applied to the skin of rabbits. The animals were observed for mortality and/or systemic effects for 14 days. No further details were provided. Acute dermal LD50/rabbits > 5000 mg/kg bw was determined.