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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Link to relevant study record(s)

Description of key information

EC50(48h)=2.3mg/L, based on OECD 202, Abe 2001
EC50(48h)=4.3mg/L, JME 2005
EC50(24h)= 6 mg/L, Knie 1983

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
2.3 mg/L

Additional information

Raveton (2006) conducted a study on Aedes aegypti, where the test animals were exposed to the substance for 24 h in a fresh water, static system. No description on the test method was provided and the LC50 was reported as 52.4 mg/L. The study was disregarded, as the test species, duration of exposure and the derived endpoint do not allow comparison with other available studies.

Knie (1983) reported the EC50= 6 mg/L based on a study conducted on Daphnia magna which were exposed for 24 h to the test substance. No method description was provided and it is unclear if the validity criteria have been fulfilled. Furthermore, the exposure duration was only of 24 h and there is no data as to whether concentrations were determined analytically. However, the value is in good agreement with the other available data.

Two studies have been carried out on Daphnia Magna with an exposure duration of 48 h. The ministry of Environment Japan (JME 2005) published only the result of the study as EC50= 4.3 mg/L. No other details was given. Whereas, Abe 2001 carried out the study based on OECD guideline 202. Many information on the method are provided such as the temperature, pH and dissolved oxygen concentration, however it lacks certain details and it is unclear whether the validity criteria were met.

As it is the most conservative value, EC50 = 2.3 mg/L is taken forward for the purpose of risk assessment. In accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.2, the available data is considered adequate for the purposes of risk assessment and classification based on a weight of evidence.