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Registration Dossier
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EC number: 800-696-3 | CAS number: 78605-96-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Summary report dated 2 January 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Not a complete report, only results presented.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The dermal LD50 value was derived for amyl cinnamic aldehyde using four treated rabbits. Clinical symptoms and mortalities were monitored.
- GLP compliance:
- not specified
- Test type:
- other: modified design based on standard method but limited to group size of four rabbits due to insufficient test material
- Limit test:
- yes
Test material
- Reference substance name:
- Heptanal, 2-(phenylmethylene)-, (2E)-
- EC Number:
- 800-696-3
- Cas Number:
- 78605-96-6
- Molecular formula:
- C14 H18 O
- IUPAC Name:
- Heptanal, 2-(phenylmethylene)-, (2E)-
- Details on test material:
- The test material typically contains >94% of the trans (E) isomer and 4-5% of the cis (Z) isomer.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data provided in report
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- Four rabbits dosed at 2 g/kg bw, no details available for duration of exposure or nature of the bandaging used or any wash-off procedures.
Insufficient test material available to treat a full group and consequently only four animals were tested. - Duration of exposure:
- No data
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 4 rabbits
- Control animals:
- not specified
- Details on study design:
- No data
- Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortalities were observed
- Clinical signs:
- other: No clinical signs observed
- Gross pathology:
- No data
- Other findings:
- No data
Any other information on results incl. tables
No additional results
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The dermal LD50 for rabbits was greater than 2.0 g/kg. According to Regulation (EC) No. 1272/2008, no classification is warranted, based on the absence of signs of toxicology and mortalities in a group of four rabbits.
- Executive summary:
In a study conducted by Moreno (1973), the dermal LD50value was derived for amyl cinnamic aldehyde in a group of four rabbits.
The dermal LD50 for rabbits was greater than 2000 mg/kg bw. According to Regulation (EC) No. 1272/2008, no classification is warranted.
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