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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Recent GLP study to current guidlines
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
yes
Remarks:
Shaken at 30 C and stood at 20 C for a shorter period to address an observed reduction in analysed concentration with longer shaking times.
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Water solubility:
> 0.547 - < 4.09 mg/L
Temp.:
20 °C
pH:
ca. 3.9

Sample Number

Time shaken at 30°C (hours)

Time equilibrated at 20°C (hours)

Concentration (g/L)

Solution pH

1A

24

24

9.30x10-4

3.91

1B

24

24

9.20x10-4

3.91

2A

48

24

6.23x10-4

3.78

2B

48

24

6.09x10-4

3.78

3A

72

24

6.07x10-4

3.76

3B

72

24

5.47x10-4

3.76

4A

1

1

3.81x10-3

3.99

4B

1

1

4.09x10-3

3.99

5A

2

1

2.90x10-3

4.09

5B

2

1

3.00x10-3

4.09

6A

3

1

2.39x10-3

4.10

6B

3

1

2.27x10-3

4.10

 

 

 

Range: 5.47x10-4 to 4.09x10-3.

Overall result:    at least 4.09x10-3 g/L at 20±0.5°C

Average = 3.94

Conclusions:
Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The water solubility of the test item has been determined to be at least 4.09x10-3 g/L of solution at 20 +/- 0.5 degrees C. However, this concentration was only achieved using an amended procedure with significantly reduced saturation and equilibrium time periods. The test item was shown to be unstable under the standard test guidlenes conditions.

Description of key information

The water solubility of the test item has been determined to be at least 4.09x10-3 g/L of solution at 20 +/- 0.5 degrees C. However, this concentration was only achieved using an amended procedure with significantly reduced saturation and equilibrium time periods. The test item was shown to be unstable under the standard test guideline conditions.

Key value for chemical safety assessment

Water solubility:
4.09 mg/L
at the temperature of:
25 °C

Additional information