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EC number: 800-696-3 | CAS number: 78605-96-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
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- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
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- Nanomaterial pour density
- Nanomaterial photocatalytic activity
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- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The experiment was done according to the standard method of in vivo micronucleus. However, in the article there is no mention of GLP status and positive control.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- Deviations:
- yes
- Remarks:
- . No positive control, only one sampling time (30hr)
- GLP compliance:
- not specified
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- Hexylcinnamaldehyde
- IUPAC Name:
- Hexylcinnamaldehyde
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: purchased from Ivanovas GmbH, Kisslegg
- Age at study initiation: 10-14 week old
- Weight at study initiation: Not reported
- Assigned to test groups randomly: [no/yes, under following basis: ] Not reported
- Fasting period before study: Not applicable
- Housing: Not reported
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: Not reported
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- - Vehicle(s)/solvent(s) used: Olive oil
- Details on exposure:
- The dose was given by i.p. injection once, using olive oil as a vehicle. Eight animals were used for each dose group.
- Duration of treatment / exposure:
- The mice were killed and bone-marrow smears were prepared 30 hr after treatment.
- Frequency of treatment:
- Single injection
- Post exposure period:
- The mice were killed and bone-marrow smears were prepared 30 hr after treatment.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0 (olive oil), 324, 540, 756 mg/kg bw
Basis:
actual ingested
- No. of animals per sex per dose:
- Eight
- Control animals:
- yes, concurrent vehicle
- Positive control(s):
- Not reported
Examinations
- Tissues and cell types examined:
- The mice were killed and bone-marrow smears were prepared 30 hr after treatment.
- Details of tissue and slide preparation:
- No further details available
- Evaluation criteria:
- If significantly different from concurrent vehicle control, the result was judged as positive.
- Statistics:
- Statistical significance was determined according to the methods of Kastenbaum & Bowman (1970).
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Vehicle controls validity:
- valid
- Negative controls validity:
- not applicable
- Positive controls validity:
- not specified
Any other information on results incl. tables
Dose (mg/kg) | Surviving/treated mice | Mean no. of micronucleated PE/1000 PE |
1 x 756 | 8/8 | 2.4 |
1 x 540 | 8/8 | 1.8 |
1 x 324 | 8/8 | 2.1 |
0 | 8/8 | 1.0 |
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
Exposure to HCA did not result in an increase in the proportion of micronucleated PCEs. - Executive summary:
In an in vivo micronucleus assay performed similarly to the OECD guideline No. 474 with minor deviations, male/female NMRI mice were exposed to alpha-Hexylcinnamaldehyde (HCA) diluted in olive oil by a single intraperitoneal dose. Different dose levels (324, 540, 756 mg/kg bw) were tested (8 animals per dose). 30 hours after the injection, the bone marrow cells were collected and one thousand polychromatic erythrocytes were observed in order to quantify the number of micronucleated polychromatic erythrocytes. Concurrent vehicle animals were used as negative control, no data was available on positive control. Under the test conditions, there was no significant increase of micronucleated polychromatic erythrocytes, if compared with the concurrent control. No mortality was observed. Therefore, under the study conditions it is concluded that HCA is not clastogenic.
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