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EC number: 216-245-3
CAS number: 1533-45-5
Table No. I
Summary of Clinical Signs of Toxicity
: Sprague Dawley Rat
Sex : Female
Group I :
Total Number of
Period of signs in days
From - to
No clinical signs observed
Day 0 - Day 14
Group I :
Group II :
Weight and Percent Body Weight Gain (g)
(mg/kg body weight)
Before Fasting Body weight
Body weight Day 7
% body weight gain
Body weight Day 14
day 7- 14
day 0- 14
Summary of Gross Pathological Findings
Gross Pathological Findings
1 - 3
No abnormality detected
4 - 6
7 - 9
10 - 12
= Terminal Sacrifice
The acute oral toxicity profile of the
given test chemical in female Sprague Dawley rats according to OECD
Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method).
Initially, three female animals were
treated at the dose level of 300 mg/kg body weight of the test item
(Step - I). Administration of the test item at 300 mg/kg did not result
in any signs of toxicity and mortality at 24 hours after the dosing. As
no mortality was observed at 24 hours after the dosing, three female
animals were added to the study and treated with the same dose of 300
mg/kg of the test item (Step - II). Administration of the test item at
300 mg/kg did not result in any signs of toxicity and mortality after
the dosing. No mortality was observed at 300 mg/kg dose group, hence
additional three female animals were treated with the higher dose of
2000 mg/kg of the test item (Step - I). Administration of the test item
at 2000 mg/kg did not result in any signs of toxicity and mortality
after the dosing. As no mortality were observed at 24 hours after the
dosing, additional three female animals were treated with the higher
dose of 2000 mg/kg of the test item (Step - II).
Administration of the test item at
2000 mg/kg did not result in any signs of toxicity and mortality after
the dosing. Gross pathological examination did not reveal any
abnormalities in animals from 300 mg/kg and 2000 mg/kg dose groups.
Therefore, the lethal concentration
(LD50) value for acute oral toxicity test was considered to be >2000
mg/kg bw, when female Sprague Dawley rats were treated with the given
test chemical orally via gavage according to OECD Guideline 423 (Acute
Oral toxicity - Acute Toxic Class Method).
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