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EC number: 216-245-3
CAS number: 1533-45-5
Test and control article identity
Blank corrected data
Mean of aliquots
The ocular irritation potential of
test article was determined according to the OECD 492 test guideline.
The MatTek EpiOcular™ model was used to assess the potential ocular
irritation of the test article by determining the viability of the
tissues following exposure to the test article via MTT. The objective of
this study was to assess the ocular irritation potential of test
article. Tissues were exposed to test article and controls for ~6 hours,
followed by a ~25 minute post-soak and approximately 18 hour recovery
after the post-soak. The viability of each tissue was determined by MTT
The mean OD570 of the negative control
tissues was 1.665 and 1.589, which met the acceptance criteria of
greater than 0.8 and less than 2.5. The mean relative viability of the
positive control tissues was 45.2 and 36.5, which met the acceptance
criterion of less than 50%. The differences in viability between
identically treated tissues were 0.03 to 5.60, which met the acceptance
criterion of less than 50%. All controls passed the acceptance criteria
for a valid study.
The mean % tissue viability of test
chemical was determined to be 95.1%. Hence, under the experimental test
conditions it was concluded that test chemical was considered to be not
irritating to the MatTek EpiOcular Tissue Model OCL-200 and being
classified as “Not classified’’.
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