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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
experimental data of read across substances
Justification for type of information:
Data for the target chemical is summarized based on the structurally similar read across chemicals
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on two hydrolysis studies as-
1. and 2.
GLP compliance:
not specified
Radiolabelling:
not specified
Analytical monitoring:
not specified
Positive controls:
not specified
Negative controls:
not specified
Transformation products:
not specified
Remarks on result:
other: Although half-life value of test chemical was not known, but it was noted that chemical is not susceptible to hydrolysis.
Remarks on result:
other: Although the half-life value of test chemical was not known, but test chemical was reported to be hydrolytically stable.
Details on results:
1. Details not known
2. The test substance is not susceptible to hydrolysis. It has only 3-membered aromatic rings associated with its structure that are generally resistant to hydrolysis. Thus, test chemical was reported to be hydrolytically stable.
Validity criteria fulfilled:
not specified
Conclusions:
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the half-life value of the test chemical was not known and was reported to be hydrolytically stable. Thus, based on this, it can be concluded that the test chemical is not hydrolysable in water.
Executive summary:

Data available for the test chemical has been reviewed to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:

The half-life of the test chemical was determined. Although half-life value of test chemical was not known, but it was noted that chemical is not susceptible to hydrolysis and thus it was reported to be hydrolytically stable. On the basis of this, test chemical isconsidered to be not hydrolysable.

In an another study, the half-life of the test chemical was determined. Although the hydrolysis half-life value of test chemical was not knownand as it has only 3-membered aromatic rings associated with its structure that is generally resistant to hydrolysis.Thus, test chemical was reported to be hydrolytically stable.

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the half-life value of the test chemical was not known and was reported to be hydrolytically stable. Thus, based on this, it can be concluded that the test chemical is not hydrolysable in water.

Description of key information

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the half-life value of the test chemical was not known and was reported to be hydrolytically stable. Thus, based on this, it can be concluded that the test chemical is not hydrolysable in water.

Key value for chemical safety assessment

Additional information

Data available for the test chemical has been reviewed to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:

 

The half-life of the test chemical was determined. Although half-life value of test chemical was not known, but it was noted that chemical is not susceptible to hydrolysis and thus it was reported to be hydrolytically stable. On the basis of this, test chemical is considered to be not hydrolysable.

 

In an another study, the half-life of the test chemical was determined. Although the hydrolysis half-life value of test chemical was not known and as it has only 3-membered aromatic rings associated with its structure that is generally resistant to hydrolysis. Thus, test chemical was reported to be hydrolytically stable.

 

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the half-life value of the test chemical was not known and was reported to be hydrolytically stable. Thus, based on this, it can be concluded that the test chemical is not hydrolysable in water.