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EC number: 216-245-3
CAS number: 1533-45-5
2,2'-(ethene-1,2-diyldi-4,1-phenylene)bis(1,3-benzoxazole)for effects in
2,2'-(ethene-1,2-diyldi-4,1-phenylene)bis(1,3-benzoxazole) (CAS no.
1533-45-5) is used as a colorants in inks, plastic, rubber and paint
etc.. It is used for whitening chemical fibers, such as the polyester
fibre, nylon fiber, polypropylene fiber etc. Also used for whitening and
brightening polypropylene plastic, hard PVC, ABS, EVA polystyrene,
polycarbonate. It is also used for polymer processing. The aim was to
assess whether the PBT criterion within Annex XIII was fulfilled
for2,2'-(ethene-1,2-diyldi-4,1-phenylene)bis(1,3-benzoxazole). The PBT
criterion was herein assessed based on experimental data in conjunction
with standardized environmental fate models. Here follows a description
of the PBT assessment.
The tested substance does not
fulfil the P criterion within Annex XIII based on the assessment that
42-days Closed Bottle test following
the OECD guideline 301 D to determine the ready biodegradability of the
test item 2,2'-(ethene-1,2-diyldi-4,1-phenylene)bis(1,3-benzoxazole)
(CAS no. 1533 -45 -5). The study was performed at a temperature of 20°C.
The test system included control, test item and reference item. Polyseed
were used for this study. 1 polyseed capsule were added in 500 ml D.I
water and then stirred for 1 hour for proper mixing and functioning of
inoculum. This gave the bacterial count as 107 to 108 CFU/ml. At the
regular interval microbial plating was also performed on agar to confirm
the vitality and CFU count of microorganism. The concentration of test
and reference item (Sodium Benzoate) chosen for both the study was 4
mg/L, while that of inoculum was 32 ml/l. OECD mineral medium was used
for the study. ThOD (Theoretical oxygen demand) of test and reference
item was determined by calculation. % degradation was calculated using
the values of BOD and ThOD for test item and reference item. The %
degradation of procedure control (reference item) was also calculated
using BOD & ThOD and was determined to be 75.3%. Degradation of Sodium
Benzoate exceeds 46.38% on 7 days & 61.44% on 14th day. The activity of
the inoculum was thus verified and the test can be considered as valid.
The BOD42 value of test chemical
2,2'-(ethene-1,2-diyldi-4,1-phenylene)bis(1,3-benzoxazole) was observed
to be 0.62 mgO2/mg. ThOD was calculated as 2.31 mgO2/mg. Accordingly,
the % degradation of the test item after 42 days of incubation at 20 ±
1°C according to Closed Bottle test was determined to be 26.83%. Based
on the results, the test item, under the test conditions, was considered
to be primary inherently biodegradable in nature.
Thus based on the available
information of the test chemical
2,2'-(ethene-1,2-diyldi-4,1-phenylene)bis(1,3-benzoxazole), it has been
concluded that chemical
2,2'-(ethene-1,2-diyldi-4,1-phenylene)bis(1,3-benzoxazole) is likely to
be not persistent (not P) in nature.
The tested substance fulfils the B
criterion within Annex XIII based on the assessment that here follows:
The estimated BCF value from
authoritative database was determined to be ranges from 7541 to
53940.68, respectively. If this chemical is released into the aquatic
environment, there should be a high risk for the chemical to
bioaccumulate in fish and food chains.
Although the BCF value indicate the
chemical to be Very bioaccumulative (vB), since only predicted data is
available for the substance, it has been concluded
bioaccumulative (B) infish and food chains.
The tested substance does
not fulfil the T criterion within Annex XIII based on the assessment
that here follows:
The tested chemical is regarded to be
not classified for carcinogenicity, mutagenicity and reprotoxicity,
Further, there is no evidence of chronic toxicity, as identified by the
classifications STOT (repeated exposure), category 1(oral, dermal,
inhalation of gases/vapours, inhalation of dust/mist/fume) or category 2
(oral, dermal, inhalation of gases/vapours, inhalation of
All of the available short-term
eco-toxicity data for fish, invertebrates and algae for the substance
indicates the LC50/EC50 value was determined to be ranges from > 0.645
to 2.391 mg/L, respectively. These value suggest that the substance is
likely to be hazardous to Aquatic organisms at environmentally relevant
concentrations and can be considered to be classified in ‘Aquatic
Chronic Category 2’ as per the CLP regulation.
There are no available long-term
By speculation, long-term NOEC for aquatic organisms were not expected
for the substance at concentration below 0.01 mg/L based on the data
The chemical was therefore not
considered as hazardous to aquatic environments as per the criteria set
out in Annex XIII.
Based on critical, independent and
collective evaluation of information summarized herein, the tested
compound fulfils the B criterion but does not fulfil the P and T
criterion and has therefore not been classified as a PBT compound within
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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