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EC number: 216-245-3
CAS number: 1533-45-5
Magnusson & Kligman guinea pig
maximization test (GPMT) was conducted on six Female Hartley strain
albino guinea pigs to assess the dermal sensitization potential of the
Induction treatment consisted of 3
intra-dermal injections and one topical induction. On day 0, a row of 3
injections of 0.1 ml test material emulsified mixture of Freund’s
complete adjuvant and saline (1:1) in olive oil was given on each side
of the 2x4 cm clipped neck . In order to enhance the sensitization,
sodium lauryl sulfate 10% in petrolatum was applied on induction area
for 24 h before the topical induction. On day 7, 0.5 g of 1.0% test
chemicals in petrolatum were occlusively applied for 48 h. The samples
were covered with lint pads which were lining with Blenderm tape.
The challenge treatment was given by
open topical application. On day 21, the flank regions of the animals
were clipped and shaved, and then 0.03 ml of test material in acetone
was applied to the skin for 72 hrs. Observations were made 48 hrs after
challenge. No positive reaction was elicited at the concentrations
Hence, the test chemical was
considered to be not sensitizing to guinea pig’s skin.
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