Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 208-419-2
CAS number: 527-60-6
the repeated dose, NOEL and NAOEL related to both male and female
animals were considered as 10 mg/kg/day because hyperplasia of stomach
squamous epithelium was noticed in both the male and the female groups
of 60 mg/kg and above.
Repeated dose toxicity
2,4,6-Trimethylphenol was studied for oral toxicity in rats in
accordance with the OECD guideline on combined repeated dose and
reproductive/developmental toxicity screening test at dosages of 0, 10,
60, and 300 mg/kg/day.
No deaths occurred in any of the treated groups. In the 300 mg/kg group,
salivation in both sexes and abnormal gait in females were noted as
post-dose symptoms. Histopathological examination revealed squamous
hyperplasia in the forestomach in the 60
and 300 mg/kg groups of both sexes, and edema in the forestomach in one
male were noted.
In addition, foveola hyperplasia and erosion in the glandular stomach in
the 300 mg/kg group were noted. Almost all the changes disappeared after
a 14-day recovery period.
Reproductive and developmental toxicity
The compound had no effects on reproductive parameters such as the
estrous cycle, mating index, fertility index, numbers of corpora lutea
or implantations, implantation index, delivery index, gestation index,
gestation length, parturition, or maternal behavior. On the
examination of neonates, there were no significant differences in the
number of offspring or live offspring, sex ratio, live birth index, or
viability index on day 4. No abnormal findings ascribable to the
compound were found in the external features, clinical signs, body
weights or necropsy of the offspring.
It was concluded from the above results that NOEL and NOAEL for the
repeated dose toxicity of 2,4,6-Trimethylphenol were 10 mg/kg/day for
both sexes, and that the NOEL and NOAEL for the
reproductive/developmental toxicity were 300 mg/kg/day for parental
animals and offspring.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again