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EC number: 208-419-2
CAS number: 527-60-6
In a GLP
compliant mouse micronucleus assay according to OECD 474, ICR mice were
exposed to the test substance by intraperitoneal
Five mice per sex were treated with 125, 250 or 500 mg/kg test
substance, vehicle or positive control article and sacrificed after 24
hours. iIn addition, 5 mice per sex treated with the vehicle or 500
mg/kg test substance were sacrificed after 48 hours. No mortality was
observed in any male or female mice. Clinical signs following dose
administration included piloerection in male and female mice at all
doses and lethargy in males and females at 250 mg/kg. In addition,
prostration and irregular breathing were observed in males and females
at 500 mg/kg bw. No appreciable reductions in the ratio of polychromatic
erythrocytes to total erythrocytes was observed in the test
article-treated groups relative to the vehicle groups suggesting that
the test substance did not inhibit erythropoiesis. No significant
increase in micronucleated polychromatic erythrocytes in test
article-treated groups relative to the respective vehicle control groups
was observed in male or female mice at 24 or 28 hours after dose
administration. The positive control induced a significant increase in
micronucleated polychromatic erythrocytes in both male and female mice.
Therefore, the test substance was concluded to be negative in the mouse
micronucleus assay using ICR mice.
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