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EC number: 208-419-2
CAS number: 527-60-6
In a GLP compliant mouse micronucleus assay according to OECD 474, ICR mice were exposed to the test substance by intraperitoneal injection. Five mice per sex were treated with 125, 250 or 500 mg/kg test substance, vehicle or positive control article and sacrificed after 24 hours. iIn addition, 5 mice per sex treated with the vehicle or 500 mg/kg test substance were sacrificed after 48 hours. No mortality was observed in any male or female mice. Clinical signs following dose administration included piloerection in male and female mice at all doses and lethargy in males and females at 250 mg/kg. In addition, prostration and irregular breathing were observed in males and females at 500 mg/kg bw. No appreciable reductions in the ratio of polychromatic erythrocytes to total erythrocytes was observed in the test article-treated groups relative to the vehicle groups suggesting that the test substance did not inhibit erythropoiesis. No significant increase in micronucleated polychromatic erythrocytes in test article-treated groups relative to the respective vehicle control groups was observed in male or female mice at 24 or 28 hours after dose administration. The positive control induced a significant increase in micronucleated polychromatic erythrocytes in both male and female mice. Therefore, the test substance was concluded to be negative in the mouse micronucleus assay using ICR mice.
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