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EC number: 208-419-2
CAS number: 527-60-6
2,4,6-Trimethyl Phenol (TMP, Mesitol)
was evaluated for its potential to cause an irritating and/or corrosive
effect on the eye in a GLP-compliant OECD 405 guideline study. Three New
Zealand White rabbits received a single ocular application of 0.1 g in
the conjunctival sac of the left eye. The test substance was washed out
after 24 hours. Pannus development was observed in three out of three
treated eyes by Day 4 of the study. Pannus development is deemed
irreversible damage to the ocular tissue and as a result, the test was
terminated. In addition, corneal opacity and effects on the iris were
observed in all treated eyes by the 24-hour observation point and
persisted for the duration of the study. Conjunctival redness was
observed in all animals by the 1 -hour observation point, progressed,
and persisted for the duration of the study. Slight chemosis was
observed in all treated eyes by the 1-hour observation point progressed
to moderate or severe chemosis by the end of the study. In conclusion,
the substance is considered to be corrosive to the eyes.
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