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EC number: 208-419-2
CAS number: 527-60-6
Preliminary irritation trial: Irritation (erythema and edema) was absent
from all sites treated with the test article concentrations of 50%, 25%,
and 10% at the 24-hour observation point.
weight: All animals gained weight during the course of the study.
observations: No abnormal clinical observations were evident in any of
the animals during the course of the preliminary irritation trial.
Phenol (TMP, Mesitol) was evaluated for its potential to produce
allergenic skin reactions in a GLP-compliant OECD 406 guideline study.
38 albino guinea pigs were selected for the study, of which twenty were
treated with the test substance, ten were used as negative controls,
five were used as positive controls and three were used in a preliminary
irritation test. The concentrations of the test substance used in the
main study were determined by the results of the preliminary irritation
test. During the induction phase 50% of the test substance was applied
once per week for 3 consecutive weeks (days 0, 7 and 14) on one side of
the animal for 6 hours. The positive control substance (0.1%
dinitrochlorobenzene, DNCB in acetone) was applied in the same manner.
The negative controls received no treatment during the induction phase.
The challenge test, on day 28, was performed on freshly clipped skin
sites of test and naïve control animals with 50% of the test substance
and 0.1% of the positive control substance for 6 hours to the positive
control animals. 24 and 48 hours after removal of the challenge skin
reactions were graded. No erythema and edema was observed in the test
substance group and negative control group. 100% reactivity was observed
in the positive control group. It can be concluded that the test
substance shows no skin sensitizing potential in guinea pigs.
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