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EC number: 208-419-2
CAS number: 527-60-6
In a GLP
compliant OECD 402 guideline study, five New Zealand White rabbits per
sex received a single topical application of 2000 mg/kg bw
2,4,6-Trimethyl Phenol (TMP, Mesitol) for 24 hours under occlusive
conditions. After an observation period of 14 days animals were
necropsied. Necrosis was observed in six out of ten animals after
removal of the test substance. The necrotic areas remained visible for
the duration of the study. No mortality was observed and no
abnormalities or lesions were noted during necropsy. The LD50 was
determined to be above 2000 mg/kg bw.
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