Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 208-419-2 | CAS number: 527-60-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Long-term toxicity to fish
Administrative data
- Endpoint:
- fish, juvenile growth test
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Aquatic ECETOC database
Cross-reference
- Reason / purpose for cross-reference:
- read-across source
Reference
- Endpoint:
- fish, juvenile growth test
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- September 2016
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: read across from supporting analogue
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
The hypothesis of this analogue approach is based on common functional groups (the target substance and the source substance are both phenols under "US-EPA New Chemical Categories"), and based on additional subcategorization on common end-point specific profiling (based on "Aquatic toxicity classification by ECOSAR") and high structural similarity (60-70% based on Dice (Atom centered fragment)).
Additional refinement was performed on the test conditions from the analogue.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Source chemical: 2,4 dimethylphenol CAS 105-67-9
Target chemical: 2,4,6-trimethylphenol CAS 527-60-6
3. ANALOGUE APPROACH JUSTIFICATION
Please refer to the attached report generated by OECD QSAR Toolbox v.3.4
4. DATA MATRIX
Please refer to the attached report generated by OECD QSAR Toolbox v.3.4 - Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- other: ECHA Guidance R.6
- Key result
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 2.23 mg/L
- Remarks on result:
- other: predicted NOEC from read across approach
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The predicted NOEC on growth rate from 28 days long term toxicity test on Pimephales promelas is 2.23 mg/L (based on read across approach from structural analogue).
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of phenol, 2,4-dimethylphenol, 2,4-dichlorophenol, and pentachlorophenol on embryo, larval, and early-juvenile fathead minnows (Pimephales promelas)
- Author:
- Gary W. HolcombeGary L. PhippsJames T. Fiandt
- Year:
- 1 982
- Bibliographic source:
- Arch Environ Contam Toxicol 11:73
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 210 (Fish, Early-Life Stage Toxicity Test)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,4-xylenol
- EC Number:
- 203-321-6
- EC Name:
- 2,4-xylenol
- Cas Number:
- 105-67-9
- Molecular formula:
- C8H10O
- IUPAC Name:
- 2,4-dimethylphenol
Constituent 1
Test organisms
- Test organisms (species):
- Pimephales promelas
Results and discussion
Effect concentrations
- Key result
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 2 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
Applicant's summary and conclusion
- Conclusions:
- Based on the data available from ECETOC database, the NOEC on growth rate from a 28-days as described in the publication "Effects of phenol, 2,4-dimethylphenol, 2,4-dichlorophenol, and pentachlorophenol on embryo, larval, and early-juvenile fathead minnows (Pimephales promelas)" is 2.0 mg/L.
This result was used as source chemical data for a read across approach.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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