2,4,6-trimethylphenol

Long-term toxicity to fish

Administrative data

Endpoint:

fish, juvenile growth test

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

Aquatic ECETOC database

Cross-reference

Reason / purpose for cross-reference:

read-across source

Reference

Endpoint:

fish, juvenile growth test

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Study period:

September 2016

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: read across from supporting analogue

Justification for type of information:

REPORTING FORMAT FOR THE ANALOGUE APPROACH

1. HYPOTHESIS FOR THE ANALOGUE APPROACH
The hypothesis of this analogue approach is based on common functional groups (the target substance and the source substance are both phenols under "US-EPA New Chemical Categories"), and based on additional subcategorization on common end-point specific profiling (based on "Aquatic toxicity classification by ECOSAR") and high structural similarity (60-70% based on Dice (Atom centered fragment)).
Additional refinement was performed on the test conditions from the analogue.

2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Source chemical: 2,4 dimethylphenol CAS 105-67-9
Target chemical: 2,4,6-trimethylphenol CAS 527-60-6

3. ANALOGUE APPROACH JUSTIFICATION
Please refer to the attached report generated by OECD QSAR Toolbox v.3.4

4. DATA MATRIX
Please refer to the attached report generated by OECD QSAR Toolbox v.3.4

Reason / purpose for cross-reference:

read-across: supporting information

Qualifier:

according to guideline

Guideline:

other: ECHA Guidance R.6

Key result

Duration:

28 d

Dose descriptor:

NOEC

Effect conc.:

2.23 mg/L

Remarks on result:

other: predicted NOEC from read across approach

Validity criteria fulfilled:

not applicable

Conclusions:

The predicted NOEC on growth rate from 28 days long term toxicity test on Pimephales promelas is 2.23 mg/L (based on read across approach from structural analogue).

Data source

Reference

Reference Type:

publication

Title:

Effects of phenol, 2,4-dimethylphenol, 2,4-dichlorophenol, and pentachlorophenol on embryo, larval, and early-juvenile fathead minnows (Pimephales promelas)

Author:

Gary W. HolcombeGary L. PhippsJames T. Fiandt

Year:

1982

Bibliographic source:

Arch Environ Contam Toxicol 11:73

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 210 (Fish, Early-Life Stage Toxicity Test)

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2,4-xylenol

EC Number:

203-321-6

EC Name:

2,4-xylenol

Cas Number:

105-67-9

Molecular formula:

C8H10O

IUPAC Name:

2,4-dimethylphenol

Test organisms

Test organisms (species):

Pimephales promelas

Results and discussion

Effect concentrations

Key result

Duration:

28 d

Dose descriptor:

NOEC

Effect conc.:

2 mg/L

Conc. based on:

test mat.

Basis for effect:

growth rate

Applicant's summary and conclusion

Conclusions:

Based on the data available from ECETOC database, the NOEC on growth rate from a 28-days as described in the publication "Effects of phenol, 2,4-dimethylphenol, 2,4-dichlorophenol, and pentachlorophenol on embryo, larval, and early-juvenile fathead minnows (Pimephales promelas)" is 2.0 mg/L.
This result was used as source chemical data for a read across approach.