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EC number: 201-304-8
CAS number: 80-73-9
The developmental toxicity of the substance was investigated in a study
which was conducted under GLP conditions and in accordance with the
standardised guideline OECD 414.
During the study, groups of 25 time-mated female rats were exposed
dermally to test material at levels of 0, 10, 100 or 400 mg/kg bw/day
for 6 hours per day on days 6-15 of gestation. rats were evaluated for
clinical signs, dermal irritation, feed consumption and body weight
gains. All rats were sacrificed on gestation day 21. The ovaries were
examined for number of corpora lutea and the uteri were weighed and
examined for number and type of implantations and resorptions. Fetuses
were weighed and examined for external, visceral and skeletal
Under the conditions of the study, exposure to 100 ot 400 mg/kg bw/day
resulted in dose-related decreases in feed consumption (days 6 through
21 of gestation) and body weight gains. Significant decreases in body
weights were also noted in dams exposed to 400 mg/kg bw/day.
A significant decrease in gravid uterine weight and fetal body weight,
and increase in the incidence of delayed ossification of skull bones and
cervical centra were noted in high dose fetuses. The uterine and fetal
effects observed at 400 mg/kg bw/day were interpreted to be secondary to
decreased maternal body weight and not a direct effect of the test
The NOEL were therefore determined to be 10 mg/kg bw/day for maternal
toxicity and 100 mg/kg bw/day for developmental toxicity. Since the
maternal NOEL was lower than the developmental NOEL, the substance was
not interpreted to be a selective developmental toxicant. The substance
is not teratogenic at any dose level tested.
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