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EC number: 201-304-8
CAS number: 80-73-9
There were no deaths and no signs of ill health or toxicity
observed during this study. Greasy fur on the head was noted following
each dosing occasion, this was related to unoccluded dermal
administration of a liquid formulation/vehicle and not an effect of the
No signs of dermal irritation were seen on the ear during the
There was no indication of an effect of treatment on bodyweight
gain. A loss in bodyweight was noted for all mice in the 50% treatment
group and one mouse from in the positive control group over the study
Results of preliminary investigation
Mortality and clinical signs
Substance as supplied:
Greasy fur on the head was noted following dosing on days 1 and 2. At
the pre-dose check on Day 3 signs of toxicity were noted in the both
females, these included underactivity, hunched posture, fast breathing,
partially closed eyelids, tilted trunk and irregular breathing. Approximately
80 minutes later one female died and as this
level was clearly unsuitable for administration on the main study the
remaining animal was sacrificed.
Greasy fur on the head was noted following each dosing occasion,
this was related to unoccluded dermal administration of a liquid
formulation/vehicle and not an effect of the test substance. No deaths
or signs of toxicity were seen throughout the study.
Slight erythema was observed on the ears of one mouse on Day 3.
No erythema was observed on the ears of either mouse on Days 1 to
A loss in bodyweight was noted for both mice dosed at 50% v/v over
the study period On the basis of the results from the preliminary
investigation, 50% v/v was considered a suitable high concentration for
administration in the main phase of the study.
Group dpm/node and Stimulation Index
Number of lymph nodes per animal
+ = positive
- = negative
HCA 25% v/v
† Stimulation Index of 3 or more indicates a positive result
dpm Disintegrations per minute less background count of 37.10
AOO Acetone:olive oil (4:1 v/v) (vehicle control)
HCA Hexyl cinnamic aldehyde (positive control)
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