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EC number: 201-304-8
CAS number: 80-73-9
The repeated dose toxicity of the test material was investigated in a
GLP study which was conducted accoding to a methodology similar to the
standardised guideline OECD 407.
During the study, groups of rats received DMI, formulated as a solution,
at dose levels of 6, 30 and 150 mg/kg bw/day, daily, for a period of 28
consecutive days, by oral gavage. Clinical findings, bodyweight changes,
food consumption, haematology parameters, biochemistry parameters and
urinalayses were conducted throughout the study. Following treatment on
day 28, the animals were sacrificed. Organs were weighed and macroscopic
and microscopic pathology investigation ensued.
Under the conditions of the study, the No Observed Adverse Effect Level
(NOAEL) of DMI for the males was judged to be 30 mg/kg/day each in the
conditions of this study because of the effects on the testis and
epididymis of the150 mg/kg group.
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