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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
11 May 2010 to 7 January 2011
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study carried out in compliance with an internationally recognised guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
GLP compliance:
yes
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
-0.3
Temp.:
25 °C
Remarks on result:
other: pH not reported but study conducted under neutral (unbuffered) conditions. pH is not relevant as the substance has no ionisable groups.
Conclusions:
The octanol/water partition coefficient of the substance was determined by the shake flask method to be -0.30

Description of key information

The octanol/water partition coefficient of the substance was determined by the shake flask method to be -0.30 at 25 °C.

Key value for chemical safety assessment

Log Kow (Log Pow):
-0.3
at the temperature of:
25 °C

Additional information

The octanol water partition coefficient was measured by Mitsui Chemicals, Inc., 2011, Report No.: ESD-2010 -016). Log Pow was determined according to OECD Method 107 and was considered reliable. DMI was found to have a Log Pow of -0.3 at 25°C.