Registration Dossier
Registration Dossier
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EC number: 618-690-2 | CAS number: 90982-32-4
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- other: shake-flask method
Test material
- Reference substance name:
- ethyl 2-({[(4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]amino}sulfonyl)benzoate
- EC Number:
- 618-690-2
- Cas Number:
- 90982-32-4
- Molecular formula:
- C15H15ClN4O6S
- IUPAC Name:
- ethyl 2-({[(4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]amino}sulfonyl)benzoate
- Test material form:
- solid
- Details on test material:
- - Purity: 98.8%
- Impurities: Not reported
Constituent 1
Results and discussion
Water solubilityopen allclose all
- Key result
- Water solubility:
- 8.55 mg/L
- Conc. based on:
- test mat.
- Remarks:
- in HPLC reagent-grade water
- Temp.:
- 20 °C
- pH:
- 5.29
- Key result
- Water solubility:
- 381 mg/L
- Conc. based on:
- test mat.
- Remarks:
- in well water
- Temp.:
- 20 °C
- pH:
- 8.4
- Key result
- Water solubility:
- 63 500 mg/L
- Conc. based on:
- test mat.
- Remarks:
- in pH 9 buffer
- Temp.:
- 20 °C
- pH:
- 8.81
Applicant's summary and conclusion
- Conclusions:
- Water solubility: 8.55 mg/L in HPLC-grade water; 381 mg/L in well water; 63500 mg/L in pH 9 buffer.
- Executive summary:
This study determined the solubility of the test substance in water and in pH 9 buffer. The solubility of the test substance in purified water (HPLC reagent-grade water), in well water and in pH 9 buffer at 20°C was determined using a shake-flask method according to the guideline OECD 105.
Triplicate test vessels with an excess of chlorimuron ethyl for each solvent were equilibrated at the test temperature. Aliquots were taken at three or more consecutive sampling times and were analyzed by high performance liquid chromatography using UV absorption detection at 205 nm.
The solubility of the test substance was determined to be 8.55 x 10e-4 g/100 mL (8.55 mg/L) in HPLC reagent-grade water, 3.81 x 10e-2 g/100 mL (381 mg/L) in well water and 6.35 g/100 mL (63500 mg/L) in pH 9 buffer. Excess test substance was present in the test containers at each sample point for these three solvents. A minimum of three consecutive data points had concentrations within 15% of the average solubility for both the purified water and the well water. For the study at pH 9, two of the three data points used to calculate concentration were within 15% of the average and the third data point was within 18% of the average.
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