Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 259-105-7
CAS number: 54326-11-3
There is no evidence from the experimental studies to indicate that (benzoato-O,O')hydroxy(octadecanoato-O,O')aluminium is absorbed systemically. No information on distribution, metabolism or excretion can be derived from the experimental data.
read across from aluminum, benzoate C16-18-fatty acids complexes, data
for the mammalian toxicity Annex VII and VIII endpoints have been
generated on this substance.
following conclusions can be drawn on the basis of a review of available
key experimental data from physico-chemical and toxicological studies on
the read-across substance, aluminum, benzoate C16-18-fatty acids
complexes, performed according to international technical guidelines and
in compliance with GLP in internationally recognised contract research
(Benzoato-O,O')hydroxy(octadecanoato-O,O')aluminium does not
appear to be absorbed via the gastrointestinal tract. This is supported
by the lack of systemic toxicity in the read-across substance at single
doses of up to 2000 mg/kg bw, as a suspension in arachis oil via oral
gavage in an acute oral toxicity study in female Wistar rats and also,
following repeated daily oral gavage dosing at lower concentrations to
male and female rats for at least 42 days. Alternatively, the lack of
toxicity via the oral route may also be indicative of high-threshold
toxicity for the substance over
the relatively short-term exposures examined.
not appear to be absorbed via the skin. This is supported by the lack of
any systemic toxicity in an acute dermal toxicity study at doses up to
2000 mg/kg bw in male and female Wistar rats and, also due to the
absence of any change in stimulation index following topical application
of the read-across test substance in a propylene glycol suspension in a
local lymph node assay. Although
lack of dermal absorption is the likely scenario for the absence of
systemic effects via this route of exposure, the alternative explanation
of high threshold toxicity over the short-term exposure examined cannot
be ruled out.
available data from these studies allows conclusions to be drawn
regarding distribution, metabolism or excretion of (benzoato-O,O')hydroxy(octadecanoato-O,O')aluminium.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Šajā tīmekļa vietnē tiek izmantoti sīkfaili, lai nodrošinātu Jums vislabāko lietojumu mūsu tīmekļa vietnēs.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again