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EC number: 259-105-7
CAS number: 54326-11-3
Table 1 Individual
Clinical Observations and Mortality Data
Animal Number and Sex
Effects Noted After Initiation of Exposure (Hours)
Effects Noted After Initiation of Exposure (Days)
No signs of systemic toxicity
See Overall remarks for Dermal
Reactions Tables 2 and 3.
Table 4 Individual
Bodyweights and Weekly Bodyweight Changes
Dose Level mg/kg
Bodyweight (g) at Day
Bodyweight Change (g) During Week
Table 5 Individual
Animal Numberand Sex
Time of Death
Killed Day 14
No abnormalities detected
study was performed to assess the acute oral toxicity of the test
material in the Wistar strain rat.The
acute oral toxicity of the test item to the Wistar strain rat was
assessed in a GLP-compliant study following OECD guideline 402 (adopted
1987) and Method
B3 Acute Toxicity (Dermal) of Commission Regulation
(EC) No. 440/2008
in a proprietary, experimental study (Harlan 2013). The study is
considered reliable and relevant for use for this endpoint.
Method. A group of
ten animals (five males and five females) was given a single, 24 hour,
semi occluded dermal application of the test material to intact skin at
a dose level of 2000 mg/kg bodyweight. Clinical signs and bodyweight
development were monitored during the study. All animals were subjected
to gross necropsy.
Mortality. There were no
Clinical Observations. There
were no signs of systemic toxicity.
Very slight erythema was noted at the test site of three females up to
two days after dosing. There were no signs of dermal irritation noted at
the test sites of the remaining animals.
Animals showed expected gains in bodyweight over the study period,
except for three animals which showed bodyweight loss during the first
week but expected gain in bodyweight during the second week.
abnormalities were noted at necropsy.
Conclusion. The acute
dermal median lethal dose (LD50) of aluminum,
benzoate C16-18-fatty acids complexess
in the Wistar strain rat was found to be greater than 2000 mg/kg
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