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EC number: 259-105-7
CAS number: 54326-11-3
Both aluminium and benzoic acid are expected to have a low potential for bioaccumulation, with a BCF for aluminium of around 36 at pH 7.2 and, for benzoic acid, a calculated BCF of 7.9 based on a log partition coefficient of 1.88. Considering that (benzoato-O,O')hydroxy(octadecanoato-O,O')aluminium is readily biodegradable and that fatty acids are natural substances with a long history of safe use in food, (benzoato-O,O')hydroxy(octadecanoato-O,O')aluminium is not expected to bioaccumulate in the aquatic environment.
No data are
available for the bioconcentration of (benzoato-O,O')hydroxy(octadecanoato-O,O')aluminium
in aquatic species. This endpoint can be waived if the substance has a
low potential for bioaccumulation (indicated by a log Kow <3). However,
due to the very low solubility of this substance in water and octanol,
the octanol-water partition coefficient could not be measured. Also, the
HPLC method (OECD 121) could not be used because the substance was not
soluble in typical reverse phase HPLC solvents (MeOH, MeCN and THF) thus
invalidating this method as well.
fatty acids used for the formation of the substance are either natural
substances or chemically indistinguishable from natural substances.
The fatty acid component of the substance is considered to be
non-hazardous and readily biodegradable. Fatty acids of natural origin
have a long history of safe use in foods and, under the REACH regulation
Annex V, natural C6 to C24 fatty acids are exempt from registration
(with certain caveats). Fatty acids are organic materials ubiquitous in
living organisms. These fatty acids are biotransformed via ß-oxidation
and thus have a very low potential for bioaccumulation. Benzoic acid has
a reported partition coefficient (log Kow) of 1.88 (Lide 2008) and will
therefore, in accordance with REACH Annex IX column 2, have a very low
potential to bioaccumulate (log Kow <3). Therefore, bioaccumulation data
are presented here for the aluminium component only.
et al (1991) determined the steady state bioaccumulation factor of
aluminium in brook trout Salvenlinus
The flow-through experimental
procedure followed sound scientific principles and is
considered reliable and suitable for use for this endpoint.The
fish were exposed to a steady state nominal aluminium concentration of
200 µg/L for 56 days followed by a 28-day depuration period. Duplicate
studies were run at nominal pH of 5.3, 6.1 and 7.2. The whole fish
estimated steady state BCF, which were inversely related to pH, was 215
at pH 5.3, 123 at pH 6.1 and 36 at pH 7.2. The estimated time to 90%
steady state was 1.5 days at pH 5.3, 4.2 days at pH 6.1 and 1.7 days at
pH 7.2. The fish eliminated aluminium rapidly with biological half-life
of 0.46 days at pH 5.3, 1.26 days at pH 6.1 and 0.52 days at pH 7.2.
availability of aluminium in the aqueous environment is very dependent
on pH. Soluble aluminium species are only readily available to aquatic
species at pH < 4. At neutral pH, aluminium will be in the form of
essentially insoluble hydrated oxide species, which reduces their
bioavailability by direct
and the fatty acid and benzoic acid components are considered not to
bioaccumulate in theaquatic
environment the substance isnot
expected to pose a risk of secondary poisoning.Furthermore,
realistic use scenarios, the aluminium thickener will be contained in
base oil, with the formulated greases specifically designed to minimise
the leaching of the thickener. Therefore, during use, the concentrations
of the substance which would be bioavailable are further limited.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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