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EC number: 259-105-7
CAS number: 54326-11-3
isolated form of the read-across test substance, aluminum, benzoate
C16-18-fatty acids complexes was used for these studies.
bacterial reversion assay (Ames test) was conducted on aluminum,
benzoate C16-18-fatty acids complexes together with a micronucleus assay
in human lymphocytes. In the Ames test, no significant increases in the
frequency of revertant colonies were recorded for any of the strains of
bacteria at any dose level, up to the maximum recommended, either with
or without metabolic activation or exposure method. In the micronucleus
test, aluminum, benzoate C16-18-fatty acids complexes did not induce
statistically significant increase in the frequency of cells with
micronuclei in cultured human peripheral blood lymphocytes when tested
up to a limit of solubility in both the absence and presence of a rat
liver metabolic activation system (S-9).
In the case
of both studies the results were negative, therefore aluminum, benzoate
C16-18-fatty acids complexes was considered to be non-mutagenic,
non-clastogenic and non-aneugenic under the conditions of these tests.
Classification for mutagenicity generally
requires positive results from appropriate in vivo studies.
Negative results from the three in vitro studies indicate that
testing in vivo is not necessary. Since negative results were
observed in all studies conducted,
(benzoato-O,O')hydroxy(octadecanoato-O,O')aluminium is not classified
for genetic toxicity.
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