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EC number: 232-140-5
CAS number: 7789-00-6
Foetotoxicity, including post-implantation losses, was observed in the
mouse following the administration of potassium dichromate in drinking
water during gestation (days 0-19). Significant developmental effects
occurred at the lowest dose level tested, 60 mg/kg bw/d (20 mg Cr(VI)/kg
bw/d) in the absence of maternal toxicity. Qualitatively similar
results were obtained in another study in which (350 mg/kg bw/d)
potassium dichromate (125 mg Cr(VI)/kg bw/d) was administered for a
shorter period, on days 6-14 of gestation. In a pregestational study in
female mice, fetotoxic effects were seen starting from the lowest dose
level tested, 250 ppm (63 mg/kg bw/d (22.1 mg Cr(VI)/kg bw/d)) potassium
dichromate. Significant levels of total chromium were found in treated
animals at sacrifice.
The results of developmental toxicity studies of various designs and
reliabilities performed in the mouse with potassium dichromate show that
this compound is a developmental toxin; similar activity is assumed for
the other compounds in this group.
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