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EC number: 232-140-5
CAS number: 7789-00-6
The significantly lower liver weights seen in females treated with
sodium dichromate are not considered to be of toxicological significance
as they are associated with low concurrent control values.
Sodium chromate, sodium dichromate and potassium dichromate (moistened
with saline) were administered for 24 hours under occluive conditions to
the shorn dorsal skin of groups of New Zealand White Rabbits (5/sex).
Animals were observed for 14 days.
Deaths occurred in the groups treated with sodium chromate (1F), sodium
dichromate (1M, 3F) and potassium dichromate (2F). Signs of systemic
toxcity and local dermal effects were observed in each treatment group.
Bodywieghts were unaffected by treatment. Gross necropsy did not reveal
any clearly treatment-related effects. Significantly higher absolute
and relative liver weights seen in sodium dichromate-treated animals are
associated with low concurrnet controls and are considered to be of
minimal toxicological significance.
The acute dermal LD50 values for each of the compounds investigated was
therefore found to be >2000 mg/kg bw.
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