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EC number: 232-140-5
CAS number: 7789-00-6
The results of the reviewed studies indicate that the dermal absorption
of chromate from water soluble Cr (VI) compounds is likely to be low.
Dermal absorption values of 1 -4% were found in guinea-pig studies,
however these are likely to be over-estimates.
The dermal absorption of Cr (VI) has been stdueis in guinea pigs
following the application of aqueous solutions of 51Cr-labelled
chromate. Generally less than 1% of the dose was absorbed when animals
were exposed to concentrations of between 0.48 mM and 4.87 M for 5
hours. At concentrations of 0.261 M and 0.398 M, 4% and 2.8% of the
applied dose was absorbed, respectively. The UK IOH review cautions
that, as dermal absorption was deteremined by measuring the
disappearance of radiolabel from the applied dose, the reported figures
include material residual in the skin at study termination. The reported
dermal absorption figures may therefore be overestimates as material in
the skin may not be systemically available.
An additional guinea pig study reported absorption (radioactivity in the
carcass and excreta) of 1.4% after 24 hours; the findings of this study
are therefore consistent with the earlier studies. Based on
considerations of the comparative structure of human and guinea-pig
skin, it can be concluded that the dermal absorption of water-soluble
hexavalent chromium compounds in occupationally-exposed humans is likley
to be negligible.
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