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EC number: 232-140-5
CAS number: 7789-00-6
Adverse effects were produced in mice receiving potassium dichromate for
12 weeks in drinking water at 333 mg/kg bw/d (120 mg Cr(VI)/kg bw/d) and
400 mg/kg bw/day (140 mg Cr(VI)/kg bw/d) and above in males and females
respectively. An increase in resorptions following treatment of males
and a decrease in implantations in treated females were among the
findings in this study. In another study, pregestational oral
administration of potassium dichromate in drinking water to female mice
produced adverse effects on fertility (reduced number of corpora lutea
and increased pre-implantation loss) at 500 ppm (119 mg/kg bw/d (40 mg
Cr(VI)/kg bw/d)) and above. In a third study, also in the mouse, at 86
mg/kg bw/d (30 mg Cr(VI)/kg bw/d), the highest dose level tested, there
were no effects of treatment on fertility parameters.
The results of studies performed using the administration of potassium
dichromate in drinking water show adverse effects on the fertility of
male and female mice. Based on the comparable toxicokinetics and
toxicodynamics of the water-soluble hexavalent chromium compounds;
similar toxicity can be assumed for all of the compounds in this group.
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