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EC number: 232-140-5
CAS number: 7789-00-6
Groups of rats (5/sex) were gavaged with single doses of sodium
chromate, sodium dichromate or potassium dichromate (in water) at dose
levels of between 10 and 300 mg/kg bw. Animals were observed for 14
days. Bodyweights were recorded on Days 1, 4, 7, 11 and 14. Gross
necropsy was performed on all animals and organ weights recorded.
Deaths occurred at dose levels of >=75 mg/kg bw (sodium chromate,
sodium, dichromate) and at >=100 mg/kg bw (potassium dichromate):
females were slightly more sensitive than males for all compounds.
Signs of toxicity were observed in all groups and included hunched
posture, tremors, hypokinesia, sedation, prostration, coma,
piloerection, ataxia, diarrhoea, dacryorrhoea and hyperkinesia.
Slightly reduced weight gain was seen in some surviving animals.
Findings at necropsy were limited to reddening and staining of the
stomach, abnormal gastric contents and green staining of the lungs.
Organ weights were unaffected by treatment.
LD 50 values were calculated to be:
Sodium chromate: 129.5 (118.5 -142.0) mg/kg bw in males; 67.0 (58.5
-77.0) mg/kg bw in females
Sodium dichromate: 123.5 (107.0 -142.5) mg/kg bw in males; 86.5 (74.0
-101.0) mg/kg bw in females
Potassium dichromate: 168.0 (154.5 -182.5) mg/kg bw in males; 90.5
(81.5 -100.5) mg/kg bw in females
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