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EC number: 204-317-7
CAS number: 119-36-8
The results for a supplemental study:
One male test animal died on day 11, the two others died on day 19. The
females died on days 31, 40 and 71. Rough hair coat and growth
inhibition was observed for all test animals, with some animals having
Grossly, four of the six treated rats had slight to moderate lung
damage. Focal gastric hemorrhages were present in the glandular portion
of three of the test animals. Bone growth was affected.
of the limbs showed reduced length and diameter compared to controls.
Density of the hypophysis of long bones was increased.
Webb and Hansen (1963) administered methyl salicylate in the diet to
groups of male and female Osborne-Mendel rats at concentrations of 0,
0.1%, 0.5%, 1.0% or 2.0% in the diet providing doses of approximately 0,
50, 250, 500, and 1000 mg/kg bw/day for two years. All rats in the 1000
mg/kg group died by the 49th week. Body weight of both sexes was
significantly decreased in the 500 and 1000 mg/kg body weight/day groups.
An increased amount of cancellous bone was present in the metaphyses in
rats treated at either 500 or 1000 mg/kg body weight/day, with a more
marked effect at the highest dose level. The relative testis weight of
males was significantly increased as were the relative weights of the
heart and kidneys of females in the 500 mg/kg body weight/day group.
Gross pituitary gland lesions were increased
at 250 but not 500 mg/kg bw/day compared to controls.
on this study, the NOAEL value is 50 mg/kg body weight/day.
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