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EC number: 204-317-7
CAS number: 119-36-8
Abbott and Harrisson, 1978 conducted a study in dogs to ascertain
whether or not hepatomegaly was associated with massive daily dosages of
salicylates. In order to determine whether findings were relevant for
humans, the assistance of seven clinicians was solicited to review case
histories of children receiving salicylate therapy and whose periodic
examinations had included records of liver palpation.
A total of 218 cases were reported upon (see "cross reference to other
study"). Salicylate dosages ranged up to 4800 mg/day over periods of up
to 8 or 10 years. It was consensus of the reporting clinicians that
salicylate therapy does not cause hepatomegaly. Nor does salicylate
therapy interfer with growth or weight gain. It was reported however,
that hepatomegaly is occasionally seen upon admission or during the
course of treatment. Such was viewed as a concurrent happening which if
encountered regresses as the disease condition is brought under control
by salicylate therapy.
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