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EC number: 204-317-7
CAS number: 119-36-8
The methyl ester of
was distributed in vivo very similarly to that observed with ASA and
rapidly demethylated following absorption from the stomach and is
subsequently converted to ASA and salicylate. Salicylate is the main
metabolite produced from both AMEand
ASA, which specifically accumulates in inflamed tissues.
In this study (Rainsford et al., 1980), bio-distribution in rats of
salicylic acid with low gastric ulcerogenicity was examined. The
distribution and metabolism of the radioactively labelled salicylic acid
(SA) was evaluated after oral gavage administration using whole body
autoradiography and chemical analyses. Results show that salicylic acid
is absorbed as it was rapidly found in blood. Moreover, salicylic acid
is distributed in several organs in the body. Qualitative organ
distribution of radioactivity : ASA (100 mg/kg): Non glandular mucosa of
stomach = kidneys = inflamed paws > lungs > glandular mucosa of stomach
= liver = bone marrow = intestine. SA (10 and 100 mg/kg): Non glandular
mucosa of stomach = inflamed paws > lungs > liver >= glandular mucosa of
stomach = kidneys = bone marrow = intestine.
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