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EC number: 204-317-7
CAS number: 119-36-8
The acute inhalation toxicity of salicylic acid was tested. Six male
Albino rats were exposed for 1 hour to 0.9 mg/L of salicylic acid as a
dust (measured concentration). They were then observed for 14 days.
Under the conditions of the test, the 1 -hr LC50 was greater than 0.9
mg/L (measured concentration). No mortality was observed and no
significant findings were reported at necropsy. Clinical signs of
irritation were restricted to salivation, nasal discharge, and
lacrimation in one animal at 15 -30 minutes after exposure only.
Although the study has limitations in that the exposure duration was one
rather than four hours, at a concentration lower than the standard limit
dose, it was clear that there was no evident toxicity and minimal
No data were reported on particle size distribution, however data from
typical production batches indicate that less than 5% of particles fall
into the respirable range (MMAD <4um). Median MMAD is in the range 35
-50 um, with up to 20% non-inhalable particles > 100 um. The majority of
inhaled particles are therefore impacted in the nasal region and
transferred to the digestive tract.
It is considered that this study is adequate to fulfil this endpoint,
which is a minor route of exposure for this substance.
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