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EC number: 204-317-7
CAS number: 119-36-8
For each of the 5 preparations containing MeS, MeS was absorbed
and mainly converted to SA during transport through the skin.
In a study to examine dermal penetration of MeS from a topical
preparation, dogs (5 male greyhounds) were anaesthetised and
microdialysis probes placed in the dermis and gluteal muscle over each
coxofemoral (hip) joint.. MeS was applied topically over the left hip
joint. Dialysate and plasma (blood samples from the cephalic and femoral
veins) were obtained during the subsequent 5 hours. Dogs were
euthanatized, and tissue samples and synovial fluid were collected and
analyzed for MeS and SA by use of HPLC.
SA and MeS concentrations increased rapidly (<30 minutes after
application) in dialysate obtained from treated dermis. SA also appeared
in plasma within 30 minutes and reached a plateau concentration after 2
hours, although combined concentrations (SA plus MeS) in plasma obtained
from femoral vein samples were twice concentrations (SA only) measured
in plasma obtained from the cephalic vain. Treated muscles had a
progressive decrease in concentration of SA plus MeS, but it was
substantially higher than that in untreated muscle. Substantial amounts
of SA and MeS were also measured in synovial fluid of treated joints.
Topically applied MeS can penetrate deeply into tissues. Local
concentrations higher than circulating systemic concentrations are
suggestive that direct diffusion and local blood redistribution
contribute to this effect.
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