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EC number: 204-317-7
CAS number: 119-36-8
No toxic signs and no macroscopic or microscopic effects were seen at
necropsy following exposure to a saturated atmosphere for 7 hours per
day, 5 days per week for 4 weeks.
4 female Alderley Park rats weighing an average of 200 g were exposed to
a dynamic atmosphere (atmosphere continuously generated and passed
through the exposure chamber) containing a saturated atmosphere (700
mg/m3) of methyl salicylate for 7 hours per day, 5 days per week for 4
weeks. Food and water were available ad libitum. Animals were weighed
each day, and their condition and behaviour were recorded throughout the
exposure period. Urine was collected overnight after the last exposure
day for biochemical testing. Gross necropsy was conducted as well as
microscopic examination of organs. Methyl salicylate at 700 mg/m3 (120
ppm), the maximum achievable atmosphere, did not cause any adverse
effects (Gage, 1970).
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