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EC number: 701-368-1
CAS number: 1962138-75-5
sub-chronic 26-week repeated dose toxicity study was conducted in male
and female CRJ-SD rats to evaluate the effects of C10-13 LAS, magnesium
salt. The test substance was applied daily on the shaved backs of
animals at dose levels of 0, 0.5, 1.0 and 5.0% dissolved in 3%
polyethylene glycol (PEG) for 26 weeks with 20 animals/sex/dose group.
General symptoms and body weight of animals were recorded on a
daily-basis and food intake were recorded weekly. Urinalysis and
haematological examinations were performed on Weeks 5 and 13 and also at
termination, along with clinical biochemical examination. All the
surviving animals were humanely euthanized after 26 weeks and organs
were collected for recording absolute and relative weights and
histopathological observation. There was slight reduction of body weight
in males at 0.5% at the end of the study. No toxicologically significant
changes were observed in food consumption, urinalysis, haematological
and serum biochemical findings. No changes were seen in the organ
weights and gross pathology of the collected organs. Histopathological
findings were non-specific and had no dose-dependency. Under the study
conditions, the systemic toxicity NOAEL was established at 5.0%
(equivalent to 2500 mg/kg bw/day), based no toxicologically relevant
changes at any dose level (Ito, 1978d).
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