Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-368-1 | CAS number: 1962138-75-5
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
Description of key information
Additional information
The aim of study was to evaluate the effects of monoethanolamine on oxaluria and oxalate deposition in the kidneys of male and female rats. Male and female rats, Wistar strain, each weighing approximately 180 g, were fed either a control diet consisting of Purina Laboratory Chow or the control diet supplemented with 2% ethanolamine over a period of 36 days. Food and water were provided ad libitum. The daily food intake was noted in the study. The 48 hour urine sample was collected every 12 days and oxalic acid content was determined. At the completion of the experimental period the animals were euthanized and the kidneys were removed. The oxalic acid content was also determined in kidneys. Homogenates or tissue slices of liver or kidney were incubated in a milieu containing a C14-labeled substrate, ethanolamine-1,2-C14. Results revealed that supplementation of the control diet with 2% ethanolamine failed to stimulate oxalate excretion with either sex. Ethanolamine also had no effect on kidney oxalate deposition. There was no metabolic variation between male and female rats in the metabolism of possible C14-labeled oxalic acid precursors. No metabolism of oxalic-1,2-C14 acid was detected in either sex.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
