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EC number: 287-335-8
CAS number: 85480-55-3
The aim of study was to evaluate the effects
of monoethanolamine on oxaluria and oxalate deposition in the kidneys of
male and female rats. Male and female rats, Wistar strain, each weighing
approximately 180 g, were fed either a control diet consisting of Purina
Laboratory Chow or the control diet supplemented with 2% ethanolamine
over a period of 36 days. Food and water were provided ad libitum. The
daily food intake was noted in the study. The 48 hour urine sample was
collected every 12 days and oxalic acid content was determined. At the
completion of the experimental period the animals were euthanized and
the kidneys were removed. The oxalic acid content was also determined in
kidneys. Homogenates or tissue slices of liver or kidney were incubated
in a milieu containing a C14-labeled substrate, ethanolamine-1,2-C14. Results
revealed that supplementation of the control diet with 2% ethanolamine
failed to stimulate oxalate excretion with either sex. Ethanolamine also
had no effect on kidney oxalate deposition. There was no metabolic
variation between male and female rats in the metabolism of possible
C14-labeled oxalic acid precursors. No metabolism of oxalic-1,2-C14 acid
was detected in either sex.
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