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EC number: 701-368-1
CAS number: 1962138-75-5
Formula for calculation of mating index:
Mating index: (number of confirmed mating/
number of animals cohabitated) X 100
Table 1: Mating index of the maternal
animals (Palmer et.al., 1975)
Number of confirmed mating
Number of animals cohabitated
Table 2: Summary of adult performance
(Palmer et.al., 1975)
Table 3: Group mean litter data (Palmer
Dosage (mg/kg bw/day)
A: Mean value includes all surviving animals
showing evidence of implantation, including those with total litter loss
B: Mean value includes only animals bearing
viable young at termination
Difference from controls statistically
significant at Wilcoxon test: aP < 0.05 and bP < 0.001.
a) Group mean incidence for major
and minor malformations (Palmer et.al., 1975)
b) Group mean incidence for pups with
extra ribs (Palmer et.al., 1975)
* Young showing major malformations excluded
pre-natal developmental toxicity study is conducted with C10-13LAS,
sodium salt in pregnant female CD rats. The test substance was
administered to groups of 20 pregnant female rats via oral gavage at
doses of 0, 0.2, 2, 300 and 600 mg/kg bw/day from gestation day 6 (GD 6)
till GD 15. All animals were observed daily for clinical signs of
toxicity and were weighed regularly throughout the gestation. On GD 17,
animals were euthanised and uteri were examined for number of
implantations, viable youngs and embryonic deaths (abortion or
resorption sites). Ovaries were examined and number of corpora lutea
were also recorded. Individual foetus was weighed and examined for
external malformations. About one third of the foetuses were examined
for visceral anomalies and remaining two thirds for skeletal anomalies.
Moderate maternal toxicity was observed at the highest dose due to
retarded weight gain and mortality. These effects were associated with
the gastrointestinal disturbances. No instances of major, minor and
skeletal malformations were observed up to the highest dose of 600 mg/kg
the exception of a marginal retardation of sternebral ossification at
Based on the results, the maternal toxicity and developmental toxicity
NOAELs were determined to be 300 mg/kg bw/day based on retarded weight
gain and mortality in treated females at higher dose and based on
absence of major, minor and skeletal malformations at highest dose
respectively (Palmer, 1975a).
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