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EC number: 701-368-1
CAS number: 1962138-75-5
The objective of the study was to determine
the acute dermal toxicity of 2-aminoethanol when applied once to the
intact rabbit skin.
New Zealand White rabbits weighing between 2
- 3 kg were used in this study. The test material was applied at
following three doses (five animals/sex/dose) by adjusting its volume:
1.0, 2.0, or 4.0 mL/ kg bw.
Rabbits were subjected to 24 hours of
contact to 2 -aminoethanol retained under impervious sheeting on the
clipped and intact skin of the trunk. Vetrap Bandaging Tape was wrapped
over the impervious sheeting and the animal was returned to its cage for
the contact period. Gauge was also wrapped around the trunk over sample
to prevent leakage in case of larger doses. After the contact period,
excess fluid was removed to diminish ingestion.
Post treatment, all animals were observed
for mortality, clinical signs, skin reactions and body weight changes
for 14 days. After 14 days of observation, all surviving animals were
euthanized, subjected to necropsy and examined for gross pathological
No mortality was observed at 1.0 mL/kg bw
dose. One male within two days and one female at day 13 died at 2.0
mL/kg bw dose while five males and four females died at 4.0 mL/kg bw
within two days.
Erythema, edema, necrosis scabs and
ulceration were observed in treated animals at 1.0, 2.0, or 4.0 mL/kg bw
doses. Apart from these effects, at 1.0 mL/kg bw desquamation was
observed in both sexes while abdominal distension, emaciation and
audible breathing were also observed in female animals.Animals treated
with 2.0 mL/kg bw showed sluggishness (both sexes) along with emaciation
(male) and abdominal distention (female). Recovery was observed in
survivors at this dose after two days. In high dose group (4.0 mL/kg
bw), prostation was obseved in single male along with sluggishness in
single female at day 1. One female rabbit also showed recovery after 2
days at high dose.
No abnormal changes in body weight were
In all treated animals, changes in color and
texture were observed in multiple internal organs of all animals at all
doses. Instances of intestinal hemorrhage were observed in both sexes at
high dose and a single instance was also reported in a female at low
dose. At high dose, nothing remarkable was observed in the female
Based on the above, the acute dermal (LD50)
of 2 -aminoethanol was determined to be in range of 2.46- 2.83 mL/kg bw
in New Zealand White rabbits when applined on the intact skin. LD50
value of 2504 (95% CL: 1822 - 3451) mg/kg bw and 2881 (95% CL: 1639 -
5070) mg/kg bw for males and females New Zealand White rabbits,
respectively was also determined in this study.
The test material is therefore classified as
Category 5 based on GHS criteria.
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