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EC number: 287-335-8
CAS number: 85480-55-3
1: Water Solubility Results of MEA-LAS (study # 85858)
concentration obtained from flask 1 was higher. This was suspected to be
due to the presence of aggregation in the aliquot prior to dilution. As
a result, the concentration of flask 1 was considered an outlier.
water solubility of MEA-LAS was determined by following EU Method A.6
the preliminary pest, the aqueous solubility of MEA-LAS was estimated by
incrementally adding known amounts of water to 338 mg of the test
material in a vial. After each addition of the known amount of water,
the mixture was shaken vigorously for about 10 minutes and then visually
checked for any un-dissolved parts of the sample. This process was
repeated until complete dissolution of the sample occurred. The aqueous
solubility was estimated from the amount of sample to volume of water as33.8
main test, to minimize the effect of micelles on the analysis, different
amounts of the test material was used to saturate 100 mL of water in
three flasks. For flask 1, 5.7 g was used for the saturation of the
water, 3.93 g for flask 2 and 4.35 g for flask 3. The three flasks were
then shaken at a temperature of 30°C in an incubated shaker at 200 rpm.
Flask 1 was saturated for duration of 24 hours, flask 2 for 48 hours and
flask 3 for 72 hours.
flask was then allowed to equilibrate for 96 hours prior to
concentration analysis via UV spectrophotometry.
water solubility of MEA-LAS was determined as 36.6 g/L (pH 8.45),
(determined by EU Method A.6 (Water Solubility)).
water solubility test is classified as acceptable, and satisfies the
guideline requirements of the EU Method A.6 (Water Solubility)).
water solubility of MEA-LAS was determined following EU Method A.6
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