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EC number: 287-335-8
CAS number: 85480-55-3
The objective of this study was to determine
the acute oral toxicity (LD50) of 2-aminoethanol when administered once
orally to male and female rats.
Male and female Sprague-Dawley rats were
used in this study. The test material was administered by oral gavage as
2% (200 mL/kg bw), 4% (400 and 800 mL/kg bw), 8% (1000 and 1250 mL/kg
bw) and 20% (1600 and 3200 mL/kg bw) aqueous solutions to the animals
(10 rats/dose). These doses corresponds to 200, 404, 808, 1010, 1262.5,
1616 and 3232 mg/kg bw (calculated on the basis of density of 1.01 g/ mL
at 20 °C).
Post treatment, animals were examined for
mortality, clinical signs and body weight changes upto day 7. After 7
days of observation, all surviving animals were euthanized, subjected to
necropsy and examined for gross pathological changes. Mortalities were
observed in all animals treated with 3200 mL/kg bw dose within 24 hours
while two males and four females died within first 48 hours in the group
treated with 1600 mL/kg bw. No mortality was observed in animals treated
with 200, 400, 1000 and 1250 mL/ kg bw doses.
At 3200 and 1600 mL/kg bw doses, animals
exhibited calm behaviour and abdominal position after application.
Animals treated with 1600 mL/kg bw dose also exhibited slight staggering
and piloerection during observation till day 7. Squatting posture and
calm behaviour was observed upto 24 hours after treatment in 1250 and
1000 mL/kg bw dose groups and no clinical signs were noted in these
groups after day 4. No clinical signs were observed in 800 and 400 mL/kg
bw dose groups while slight staggering was noted in animals treated with
200 mL/kg bw on first two days of this study and no clinical signs were
observed later on. No abnormal changes in body weight were reported. No
abnormal gross pathological alterations were observed at the end of 7
days observation period in
surviving animals at necropsy.
Based on the above observation, the acute
oral toxicity (LD50) of 2-aminoethanol was determined to be ca. 1515
mg/kg bw (ca. 1500 ml/kg bw; calulated with a specific density of 1.01
The test material is therefore classified as
Category 4 based on GHS criteria.4
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